1. Cell Cycle/DNA Damage NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  2. ATF6 Reactive Oxygen Species
  3. 393121-74-9

393121-74-9

AA147 Chemical Structure

393121-74-9

Chemical Structure

  • AA147
  • CAS No: 393121-74-9
    Formula: C16H17NO2
    Molecular Weight: 255.31
  • IUPAC Name: N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
  • InChIKey: AWHLTHOHBAGPMY-UHFFFAOYSA-N
  • SMILES: O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2

Biological Activity: AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[1][2][3][4].

References

Keywords:

AA147