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397290-30-1

Gue1654 Chemical Structure

397290-30-1

Chemical Structure

  • Gue1654
  • CAS No: 397290-30-1
    Formula: C23H17N3OS3
    Molecular Weight: 447.60
  • IUPAC Name: N-(7-(methylthio)benzo[1,2-d:4,3-d']bis(thiazole)-2-yl)-2,2-diphenylacetamide
  • InChIKey: UFOBDFMYJABXGK-UHFFFAOYSA-N
  • SMILES: O=C(C(C1=CC=CC=C1)C2=CC=CC=C2)NC3=NC4=C(S3)C5=C(N=C(SC)S5)C=C4

Biological Activity: Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ[1].

Cat. No. Product Name Purity Description
HY-110114 Gue1654 98.31% Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ.

References

[1]. Blättermann S, et al. A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer. Nat Chem Biol. 2012;8(7):631-638. [Content Brief]

Keywords:

Gue1654