2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. 285571-64-4

285571-64-4

Barusiban Chemical Structure

285571-64-4

Chemical Structure

  • Barusiban
  • Synonym(s): FE-200440
  • CAS No: 285571-64-4
    Formula: C40H63N9O8S
    Molecular Weight: 830.05
  • InChIKey: UGNGRKKDUVKQDF-IHOMMZCZSA-N
  • SMILES: O=C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@H](CCSCCC(N1)=O)C(N(C)[C@H](CO)CCCN)=O)=O)CC(N)=O)=O)([H])[C@H](C)CC)=O)([H])[C@@H](C)CC)[C@H]1CC2=CNC3=CC=CC=C23

Biological Activity: Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research[1][2][3].

Cat. No. Product Name Purity Description
HY-P3516 Barusiban Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research.

References

[1]. Helmer H, et al. Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human†. Biol Reprod. 2020 Jun 23;103(1):135-143. [Content Brief]
[2]. Reinheimer TM, et al. Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor. J Clin Endocrinol Metab. 2005 Apr;90(4):2275-81. [Content Brief]
[3]. Gimpl G, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510(1-2):9-16. [Content Brief]

Keywords:

Barusiban