2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. 505068-32-6

505068-32-6

Eggmanone Chemical Structure

505068-32-6

Chemical Structure

  • Eggmanone
  • Synonym(s): EGM1
  • CAS No: 505068-32-6
    Formula: C20H20N2O2S3
    Molecular Weight: 416.58
  • IUPAC Name: 3-(2-methylallyl)-2-((2-oxo-2-(thiophen-2-yl)ethyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
  • InChIKey: XAKJIQPEGSCYIP-UHFFFAOYSA-N
  • SMILES: O=C1N(C(SCC(C2=CC=CS2)=O)=NC3=C1C4=C(CCCC4)S3)CC(C)=C

Biological Activity: Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade[1].

Cat. No. Product Name Purity Description
HY-121037 Eggmanone Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC50 of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade.

References

[1]. Williams CH, et al. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 2015;11(1):43-50. [Content Brief]

Keywords:

Eggmanone