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438-60-8

Protriptyline Chemical Structure

438-60-8

Chemical Structure

  • Protriptyline
  • CAS No: 438-60-8
    Formula: C19H21N
    Molecular Weight: 263.38
  • IUPAC Name: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
  • InChIKey: BWPIARFWQZKAIA-UHFFFAOYSA-N
  • SMILES: CNCCCC1C2=CC=CC=C2C=CC3=CC=CC=C13

Biological Activity: Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease[1][2][3].

Cat. No. Product Name Purity Description
HY-B0949A Protriptyline Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease.
HY-B0949AS Protriptyline-d3 Protriptyline-d3 is deuterium labeled Protriptyline.

References

[1]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's disease. PLoS One. 2014 Aug 20;9(8):e105196.
[2]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34. [Content Brief]
[3]. Tiwari V, et, al. Protriptyline improves spatial memory and reduces oxidative damage by regulating NFκB-BDNF/CREB signaling axis in streptozotocin-induced rat model of Alzheimer's disease. Brain Res. 2021 Mar 1;1754:147261. [Content Brief]

Keywords:

ProtriptylineProtriptyline-d3