2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 63540-28-3

63540-28-3

Fenobam hydrate Chemical Structure

63540-28-3

Chemical Structure

  • Fenobam hydrate
  • CAS No: 63540-28-3
    Formula: C11H13ClN4O3
    Molecular Weight: 284.70
  • IUPAC Name: 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea hydrate
  • InChIKey: UNFQKKSADLVQJE-UHFFFAOYSA-N
  • SMILES: O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2.O

Biological Activity: Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction[1][2][3].

Cat. No. Product Name Purity Description
HY-108991 T-0509 T-0509 ((-)-T-0509) is a selective full agonist of the β1 receptor. T-0509 activates the cAMP signaling pathway through the β1 receptor and enhances myocardial contractility.

References

[1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. [Content Brief]
[2]. Liao S, et al. Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLoS One. 2017 Feb 23;12(2):e0171256. [Content Brief]
[3]. Keck TM, et al. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl). 2013;229(2):253-265. [Content Brief]

Keywords:

Fenobam hydrate