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  4. 2081940-67-0

2081940-67-0

INCB059872 tosylate Chemical Structure

2081940-67-0

Chemical Structure

  • INCB059872 tosylate
  • CAS No: 2081940-67-0
    Formula: C30H42N2O6S
    Molecular Weight: 558.73
  • InChIKey: ZOLYYKZGDCMNJM-CMXBXVFLSA-N
  • SMILES: OC(C1(CCC1)CN2CCC(COC)(CC2)CN[C@H]3[C@@](C4=CC=CC=C4)([H])C3)=O.O=S(O)(C5=CC=C(C=C5)C)=O

Biological Activity: INCB059872 tosylate is a potent, selective and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, enhancing H3K4 methylation, thereby increasing the expression of tumor suppressor genes. INCB059872 inhibition also promotes H3K9 methylation, thereby reducing the transcription of tumor-promoting genes[1].

Cat. No. Product Name Purity Description
HY-141677B INCB059872 tosylate INCB059872 tosylate is a potent, selective and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, enhancing H3K4 methylation, thereby increasing the expression of tumor suppressor genes. INCB059872 inhibition also promotes H3K9 methylation, thereby reducing the transcription of tumor-promoting genes.

References

[1]. Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758. [Content Brief]

Keywords:

INCB059872 tosylate