199854-00-7

Chemical Structure

O-Acetylsalicylhydroxamic acid
CAS No: 199854-00-7

Formula: C₉H₉NO₄

Molecular Weight: 195.17
InChIKey: PCFWLDHLJWUGSU-UHFFFAOYSA-N
SMILES: O=C(C)ONC(C1=C(O)C=CC=C1)=O

Biological Activity: O-Acetylsalicylhydroxamic acid is an acetylation inhibitor of prostaglandin H2 synthase that can suppress PGE2 synthesis in the body and block the cyclooxygenase activity of PGHS in vitro. O-Acetylsalicylhydroxamic acid requires the presence of the active site residue Ser-529 to act on human PGHS-1; the S529A mutant is resistant to the inactivation effects of this inhibitor^[1].

Cat. No.	Product Name	Purity	Description
HY-168766	O-Acetylsalicylhydroxamic acid		O-Acetylsalicylhydroxamic acid is an acetylation inhibitor of prostaglandin H2 synthase that can suppress PGE2 synthesis in the body and block the cyclooxygenase activity of PGHS in vitro. O-Acetylsalicylhydroxamic acid requires the presence of the active site residue Ser-529 to act on human PGHS-1; the S529A mutant is resistant to the inactivation effects of this inhibitor.

References

[1]. P J Loll, et al. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions. Mol Pharmacol. 2001 Dec;60(6):1407-13. [Content Brief]

Keywords:

O-Acetylsalicylhydroxamic acid

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