2. Others Apoptosis Cell Cycle/DNA Damage
  3. Biochemical Assay Reagents Apoptosis DNA Alkylator/Crosslinker
  4. 62-50-0

62-50-0

Ethyl methanesulfonate Chemical Structure

62-50-0

Chemical Structure

  • Ethyl methanesulfonate
  • CAS No: 62-50-0
    Formula: C3H8O3S
    Molecular Weight: 124.15
  • IUPAC Name: ethyl methanesulfonate
  • InChIKey: PLUBXMRUUVWRLT-UHFFFAOYSA-N
  • SMILES: CS(=O)(OCC)=O

Biological Activity: Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc[1][2][3][4][5][6][7][8][9][10].

Cat. No. Product Name Purity Description
HY-W015854 Ethyl methanesulfonate 98.33% Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc.

References

[1]. Stopper H, et al. Induction of micronuclei in human cell lines and primary cells by combination treatment with gamma-radiation and ethyl methanesulfonate. Mutagenesis. 2002 Mar;17(2):177-81. [Content Brief]
[2]. Morris SM, et al. The role of programmed cell death in the toxicity of the mutagens, ethyl methanesulfonate and N-ethyl-N'-nitrosourea, in AHH-1 human lymphoblastoid cells. Mutat Res. 1994 Apr 1;306(1):19-34. [Content Brief]
[3]. Kojima H, et al. Combined mutagenicity of methyl methanesulfonate and ethyl methanesulfonate in Chinese hamster V79 cells. Mutat Res. 1992 Apr;266(2):171-80. [Content Brief]
[4]. Ray SD, et al. Role of cellular energy status in tocopheryl hemisuccinate cytoprotection against ethyl methanesulfonate-induced toxicity. Arch Biochem Biophys. 1994 May 15;311(1):180-90. [Content Brief]
[5]. Stavreva DA, et al. Single cell gel electrophoresis analysis of genomic damage induced by ethyl methanesulfonate in cultured tobacco cells. Mutat Res. 1998 Dec 3;422(2):323-30. [Content Brief]
[6]. Lavé T, et al. In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human. Toxicol Lett. 2009 Nov 12;190(3):303-9. [Content Brief]
[7]. Kondo K, et al. Micronucleus test with ethyl methanesulfonate administered by intraperitoneal injection and oral gavage. Mutat Res. 1989 Aug;223(4):373-5. [Content Brief]
[8]. Itoh S, et al. PIGRET assay can detect mutagenicity of ethyl methanesulfonate much earlier than RBC Pig-a assay. Mutat Res Genet Toxicol Environ Mutagen. 2016 Nov 15;811:102-105. [Content Brief]
[9]. Swann PF, et al. Induction of rat kidney tumours by ethyl methanesulphonate and nervous tissue tumours by methyl methanesulphonate and ethyl methanesulphonate. Nature. 1969 Aug 30;223(5209):947-9. [Content Brief]
[10]. Sega GA. Unscheduled DNA synthesis in the germ cells of male mice exposed in vivo to the chemical mutagen ethyl methanesulfonate. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4955-9. [Content Brief]

Keywords:

Ethyl methanesulfonate