2. Anti-infection
  3. Antibiotic
  4. 54397-84-1

54397-84-1

12S-HHT Chemical Structure

54397-84-1

Chemical Structure

  • 12S-HHT
  • Synonym(s): 12(S)-HHTrE
  • CAS No: 54397-84-1
    Formula: C17H28O3
    Molecular Weight: 280.40
  • IUPAC Name: (S,5Z,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoic acid
  • InChIKey: KUKJHGXXZWHSBG-WBGSEQOASA-N
  • SMILES: CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(O)=O

Biological Activity: 12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].

Cat. No. Product Name Purity Description
HY-113330 12S-HHT 98.40% 12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.

References

[1]. Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36. [Content Brief]
[2]. Lee JW, et al. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44(6):378-386. [Content Brief]

Keywords:

12S-HHT