2. Membrane Transporter/Ion Channel
  3. SGLT
  4. 647834-15-9

647834-15-9

Atigliflozin Chemical Structure

647834-15-9

Chemical Structure

  • Atigliflozin
  • Synonym(s): AVE-2268
  • CAS No: 647834-15-9
    Formula: C18H22O7S
    Molecular Weight: 382.43
  • IUPAC Name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-((2-(4-methoxybenzyl)thiophen-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triol
  • InChIKey: BUXGTLNOWLNUKF-SOVHRIKKSA-N
  • SMILES: O[C@H]1[C@H](OC2=C(CC3=CC=C(OC)C=C3)SC=C2)O[C@H](CO)[C@@H](O)[C@@H]1O

Biological Activity: Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC50s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus[1].

Cat. No. Product Name Purity Description
HY-14810 Atigliflozin Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC50s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus.

References

[1]. Schudok M, et al. The magic of small structure differences in a sodium-glucose cotransporter drug discovery project-14 C-labelled drug candidates in a key-differentiating study. J Labelled Comp Radiopharm. 2021 Feb;64(2):73-76. [Content Brief]

Keywords:

Atigliflozin