2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. 742693-38-5

742693-38-5

SSR504734 free base Chemical Structure

742693-38-5

Chemical Structure

  • SSR504734 free base
  • CAS No: 742693-38-5
    Formula: C20H20ClF3N2O
    Molecular Weight: 396.83
  • IUPAC Name: (S)-2-chloro-N-((1-phenylpiperidin-2-yl)methyl)-3-(trifluoromethyl)benzamide
  • InChIKey: VWBQBABOBQJMJH-HNNXBMFYSA-N
  • SMILES: O=C(C1=CC=CC(C(F)(F)F)=C1Cl)NC[C@H]2N(CCCC2)C3=CC=CC=C3

Biological Activity: SSR504734 free base is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38 nM, respectively). SSR504734 free base shows anti-schizophrenia, anti-anxiety and anti-depression activities[1].

References

[1]. Ronan Depoortère, et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology. 2005 Nov;30(11):1963-85. [Content Brief]

Keywords:

SSR504734 free base