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  6. 217461-40-0

217461-40-0

(±)-J-113397 Chemical Structure

217461-40-0

Chemical Structure

  • (±)-J-113397
  • CAS No: 217461-40-0
    Formula: C24H37N3O2
    Molecular Weight: 399.57
  • IUPAC Name: 1-((3S,4S)-1-(cyclooctylmethyl)-3-(hydroxymethyl)piperidin-4-yl)-3-ethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
  • InChIKey: MBGVUMXBUGIIBQ-RTWAWAEBSA-N
  • SMILES: O=C1N([C@](CCN2CC3CCCCCCC3)([H])[C@H](C2)CO)C4=CC=CC=C4N1CC

Biological Activity: (±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ[1].

Cat. No. Product Name Purity Description
HY-107721 (±)-J-113397 98.59% (±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a Ki of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ.

References

[1]. Ozaki S, et al. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur J Pharmacol. 2000;402(1-2):45-53. [Content Brief]

Keywords:

(±)-J-113397