2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. 83898-67-3

83898-67-3

Mioflazine di(hydrochloride) Chemical Structure

83898-67-3

Chemical Structure

  • Mioflazine di(hydrochloride)
  • CAS No: 83898-67-3
    Formula: C29H32Cl4F2N4O2
    Molecular Weight: 648.40
  • SMILES: O=C(C1N(CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)CCN(C1)CC(NC4=C(Cl)C=CC=C4Cl)=O)N.Cl.Cl

Biological Activity: Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing[1][2][3][4].

Cat. No. Product Name Purity Description
HY-U00049B Mioflazine di(hydrochloride) Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing.

References

[1]. Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl). 1987;91(4):434-9. [Content Brief]
[2]. Mioflazine, a potentially protective drug against ischaemic damage: a study in dogs [Content Brief]
[3]. Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189(6):419-22. [Content Brief]
[4]. J G Hugtenburg, et al. The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts. Eur J Pharmacol. 1990 Mar 13;178(1):71-8. [Content Brief]

Keywords:

Mioflazine di(hydrochloride)