2. Others
  3. Amino Acid Derivatives
  4. 167144-79-8

167144-79-8

R-96544 free base Chemical Structure

167144-79-8

Chemical Structure

  • R-96544 free base
  • CAS No: 167144-79-8
    Formula: C22H29NO3
    Molecular Weight: 355.47
  • IUPAC Name: (3R,5R)-5-(2-(2-(3-methoxyphenethyl)phenoxy)ethyl)-1-methylpyrrolidin-3-ol
  • InChIKey: AFZLABYDOCWQBQ-WOJBJXKFSA-N
  • SMILES: CN(C[C@@H](C1)O)[C@@H]1CCOC2=C(C=CC=C2)CCC3=CC(OC)=CC=C3

Biological Activity: R-96544 (free base) is a potent, selective and competitive 5-HT2 receptor antagonist. R-96544 (free base) inhibits platelet aggregation induced by serotonin, and inhibits 5-HT2A receptor-mediated contraction of guinea pig trachea[1].

References

[1]. Ogawa T,et al. Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor antagonist R-102444. Eur J Pharmacol. 2002;457(2-3):107-114. doi:10.1016/s0014-2999(02)02654-7 [Content Brief]

Keywords:

R-96544 free base