2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. 2924883-83-8

2924883-83-8

DPP-21 Chemical Structure

2924883-83-8

Chemical Structure

  • DPP-21
  • CAS No: 2924883-83-8
    Formula: C17H16N4S
    Molecular Weight: 308.40
  • InChIKey: WTDOSEGYWYJIAO-UHFFFAOYSA-N
  • SMILES: CC1=NC(N(C2=CC3=C(N(C=C3)C)C=C2)C)=C4SC=CC4=N1

Biological Activity: DPP-21 is an inhibitor of tubulin polymerization (IC50: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC50s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax)[1].

Cat. No. Product Name Purity Description
HY-169096 DPP-21 DPP-21 is an inhibitor of tubulin polymerization (IC50: 2.4 μM). DPP-21 shows anti-proliferative activity against cancer cell lines, with IC50s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax).

References

[1]. Xu C, et al. Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma. Eur J Med Chem. 2024 Nov 5;277:116791. [Content Brief]

Keywords:

DPP-21