1. Immunology/Inflammation
  2. FLAP
  3. 903639-13-4

903639-13-4

ALR-27 Chemical Structure

903639-13-4

Chemical Structure

  • ALR-27
  • CAS No: 903639-13-4
    Formula: C19H22O3
    Molecular Weight: 298.38
  • InChIKey: CZAHCAZTHZRDDI-UHFFFAOYSA-N
  • SMILES: OC1=CC=C(C=C1)CCC2CCC(CO2)C3=CC=C(C=C3)O

Biological Activity: ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].

Cat. No. Product Name Purity Description
HY-155408 ALR-27 ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes.

References

Keywords:

ALR-27