2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. 910462-43-0

910462-43-0

Domatinostat Chemical Structure

910462-43-0

Chemical Structure

  • Domatinostat
  • Synonym(s): 4SC-202 free base
  • CAS No: 910462-43-0
    Formula: C23H21N5O3S
    Molecular Weight: 447.51
  • IUPAC Name: (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide
  • InChIKey: PRXXYMVLYKJITB-IZZDOVSWSA-N
  • SMILES: O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2

Biological Activity: Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).

Cat. No. Product Name Purity Description
HY-16012A Domatinostat 99.43% Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1).

Keywords:

Domatinostat