2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. HDAC HSP
  4. 96017-59-3

96017-59-3

2-Hexyl-4-pentynoic acid Chemical Structure

96017-59-3

Chemical Structure

  • 2-Hexyl-4-pentynoic acid
  • Synonym(s): (±)-2-Hexyl-4-pentynoic acid
  • CAS No: 96017-59-3
    Formula: C11H18O2
    Molecular Weight: 182.26
  • IUPAC Name: 2-(prop-2-yn-1-yl)octanoic acid
  • InChIKey: DUQSBRQHALCSLC-UHFFFAOYSA-N
  • SMILES: CCCCCCC(CC#C)C(O)=O

Biological Activity: 2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons[1]. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No. Product Name Purity Description
HY-118783 2-Hexyl-4-pentynoic acid ≥98.0% 2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1]. Yan Leng, et al. Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction. Neurosci Lett. 2010 Jun 7;476(3):127-32. [Content Brief]

Keywords:

2-Hexyl-4-pentynoic acid