2. Epigenetics PROTAC
  3. Epigenetic Reader Domain PROTACs
  4. Cath-L-dBET1

Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study.

For research use only. We do not sell to patients.

Cath-L-dBET1 Chemical Structure

Cath-L-dBET1 Chemical Structure

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Cath-L-dBET1 Related Antibodies

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Description

Cath-L-dBET1 is a PROTAC degrader targeting BRD4. Cath-L-dBET1 has an IC50 value of 2.8 μM in MDA-MB-231 cells. Cath-L-dBET1 can be activated by cathepsin L (Cath-L) and recruit the E3 ubiquitin ligase and degrade BRD4 through ubiquitin-proteasome system. Hyp-dBET1 can be used for anti-tumor study[1].

Molecular Weight

1160.73

Formula

C58H66ClN11O11S
SMILES

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(NCCCCN(C(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)CC7=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C7)=O)=C(S1)N8C3=NN=C8C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Cath-L-dBET1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cath-L-dBET1Epigenetic Reader DomainPROTACsubiquitinPROTACcathepsin LMDA-MB-231 cellsInhibitorinhibitorinhibit

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