CAY10435

Cat. No.: HY-120650: FAQs
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CAY10435 is a β-ketooxazapyridine, selective FAAH inhibitor with antimicrobial activity. CAY10435 binds non-competitively to the FAAH of Dictyostelium discoideum with a Kd value of 0.57 nM.

For research use only. We do not sell to patients.

CAY10435 Chemical Structure

CAS No. : 288862-73-7

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Description

CAY10435 is a β-ketooxazapyridine, selective FAAH inhibitor with antimicrobial activity. CAY10435 binds non-competitively to the FAAH of Dictyostelium discoideum with a Kd value of 0.57 nM^[1]^[2].

IC₅₀ & Target

Ki: 0.57 nM (FAAH, Dictyostelium discoideum)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	0.017 μM Compound: 65, CAY10435	Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins before substrate addition measured after 10 mins by liquid scintillation counting analysis Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins before substrate addition measured after 10 mins by liquid scintillation counting analysis	[PMID: 24083878]

Molecular Weight

302.41

Formula

C₁₈H₂₆N₂O₂

CAS No.

288862-73-7

SMILES

CCCCCCCCCCCC(C1=NC2=NC=CC=C2O1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hayes AC, et al. Identification of N-acylethanolamines in Dictyostelium discoideum and confirmation of their hydrolysis by fatty acid amide hydrolase. J Lipid Res. 2013 Feb;54(2):457-66. [Content Brief]

[2]. Glaser ST, et al. Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. J Pharmacol Exp Ther. 2006 Mar;316(3):1088-97. [Content Brief]

CAY10435 Related Classifications

Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY10435288862-73-7CAY 10435CAY-10435FAAHFatty acid amide hydrolaseDictyostelium discoideumβ-ketooxazapyridinesantibacterialInhibitorinhibitorinhibit

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