CB-0821 

CB-0821 is a high affinity CCR5 inhibitor with a K_i of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research^[1].

CB-0821 (10-200 nM) inhibits CCR5 in Peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner, coupled with nontoxicity to Vero cells at concentrations up to 500 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

556.62

C₃₅H₂₄N₈

81430-62-8

C1(C2=NC3=NC(CC4=NN(C(C5=CC=CC=C5)=CC(C6=CC=CC=C6)=N7)C7=N4)=NN3C(C8=CC=CC=C8)=C2)=CC=CC=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ashish Kumar. CB-0821, a novel CC chemokine receptor 5 (CCR5) inhibitor with improved binding efficacy proposed as anti-HIV candidate: Computational and in vitro approach. Biotechnol Appl Biochem. 2024 Mar 31.  [Content Brief]