2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CCR HIV
  4. CB-0821

CB-0821 is a high affinity CCR5 inhibitor with a Ki of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research.

For research use only. We do not sell to patients.

CB-0821 Chemical Structure

CB-0821 Chemical Structure

CAS No. : 81430-62-8

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CB-0821 Related Antibodies

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Description

CB-0821 is a high affinity CCR5 inhibitor with a Ki of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research[1].

IC50 & Target[1]

CCR5

0.04 nM (Ki)

In Vitro

CB-0821 (10-200 nM) inhibits CCR5 in Peripheral blood mononuclear cells (PBMCs) in a dose-dependent manner, coupled with nontoxicity to Vero cells at concentrations up to 500 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB-0821 Related Antibodies
Molecular Weight

556.62

Formula

C35H24N8
CAS No.
SMILES

C1(C2=NC3=NC(CC4=NN(C(C5=CC=CC=C5)=CC(C6=CC=CC=C6)=N7)C7=N4)=NN3C(C8=CC=CC=C8)=C2)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CB-0821 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB-082181430-62-8CB0821CB 0821CCRHIVCC chemokine receptorHuman immunodeficiency virusCCR5 inhibitoranti-HIVInhibitorinhibitorinhibit

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