2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. CB096

CB096 binds the 5′CGG/3′GGC internal loop structure of r(G4C2)exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells.

For research use only. We do not sell to patients.

CB096 Chemical Structure

CB096 Chemical Structure

CAS No. : 108883-90-5

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Description

CB096 binds the 5′CGG/3′GGC internal loop structure of r(G4C2)exp RNA, interrupts its gain-of-function mechanism, and thus results in the regulation of nucleolar focusing, RNA splicing defects, RNA metabolism, nucleocytoplasmic transport dysfunction, and toxic dipeptide repeats (DPRs) generated by RNA translation. CB096 inhibits the RAN translation with an IC50 of 20 μM in HEK293T cells[1].

Molecular Weight

285.25

Formula

C14H11N3O4
CAS No.
SMILES

OC1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1OC
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Room temperature in continental US; may vary elsewhere.
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CB096 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB096108883-90-5CB 096CB-096DNA/RNA SynthesisHEK293Tamyotrophic lateral sclerosisfrontotemporal dementiaALSFTDInhibitorinhibitorinhibit

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