CB1R antagonist 1

Name: CB1R antagonist 1
Brand: MedChemExpress
SKU: HY-150067
Rating: 4.5 (1 reviews)

Cat. No.: HY-150067 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

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CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC₅₀ value of 4.2 μM and EC₅₀ value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity.

For research use only. We do not sell to patients.

CB1R antagonist 1 Chemical Structure

CAS No. : 334668-69-8

Size	Price	Stock	Quantity
5 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 145	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

hCB1-R

4.2 μM (IC₅₀)

hCB1-R

10 μM (EC₅₀)

In Vitro

CB1R Allosteric modulator 5 has cannabinoid-1 receptor (CB1R) activity with an IC₅₀value of 4.2 μM and EC₅₀ value of ＞10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.45

Formula

C₁₈H₂₃F₃N₂O₃S

CAS No.

334668-69-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCCCC1)N2CCN(S(=O)(C3=CC(C(F)(F)F)=CC=C3)=O)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (247.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4725 mL	12.3625 mL	24.7249 mL
5 mM	0.4945 mL	2.4725 mL	4.9450 mL
10 mM	0.2472 mL	1.2362 mL	2.4725 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52(8):2550-8 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4725 mL	12.3625 mL	24.7249 mL	61.8123 mL
	5 mM	0.4945 mL	2.4725 mL	4.9450 mL	12.3625 mL
	10 mM	0.2472 mL	1.2362 mL	2.4725 mL	6.1812 mL
	15 mM	0.1648 mL	0.8242 mL	1.6483 mL	4.1208 mL
	20 mM	0.1236 mL	0.6181 mL	1.2362 mL	3.0906 mL
	25 mM	0.0989 mL	0.4945 mL	0.9890 mL	2.4725 mL
	30 mM	0.0824 mL	0.4121 mL	0.8242 mL	2.0604 mL
	40 mM	0.0618 mL	0.3091 mL	0.6181 mL	1.5453 mL
	50 mM	0.0494 mL	0.2472 mL	0.4945 mL	1.2362 mL
	60 mM	0.0412 mL	0.2060 mL	0.4121 mL	1.0302 mL
	80 mM	0.0309 mL	0.1545 mL	0.3091 mL	0.7727 mL
	100 mM	0.0247 mL	0.1236 mL	0.2472 mL	0.6181 mL