2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. CBD3063

CBD3063 is a selective modulator of collapsin response mediator protein 2 (CRMP2). CBD3063 uncouples Cav2.2 from CRMP2. CBD3063 reverses neuropathic and inflammatory pain by reducing membrane expression of CaV2.2.

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CBD3063 Chemical Structure

CBD3063 Chemical Structure

CAS No. : 1281060-70-5

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Based on 1 publication(s) in Google Scholar

CBD3063 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

CBD3063 is a selective modulator of collapsin response mediator protein 2 (CRMP2). CBD3063 uncouples Cav2.2 from CRMP2. CBD3063 reverses neuropathic and inflammatory pain by reducing membrane expression of CaV2.2[1][2].

Molecular Weight

319.40

Formula

C16H25N5O2
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C(N1CCCC(C1)NC(C)=O)NCCCNC2=NC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (313.09 mM; Need ultrasonic)

DMSO : 5 mg/mL (15.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1309 mL 15.6544 mL 31.3087 mL
5 mM 0.6262 mL 3.1309 mL 6.2617 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.34%

SDS (251 KB)

COA (243 KB) HNMR (295 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.1309 mL 15.6544 mL 31.3087 mL 78.2718 mL
5 mM 0.6262 mL 3.1309 mL 6.2617 mL 15.6544 mL
10 mM 0.3131 mL 1.5654 mL 3.1309 mL 7.8272 mL
15 mM 0.2087 mL 1.0436 mL 2.0872 mL 5.2181 mL
H2O 20 mM 0.1565 mL 0.7827 mL 1.5654 mL 3.9136 mL
25 mM 0.1252 mL 0.6262 mL 1.2523 mL 3.1309 mL
30 mM 0.1044 mL 0.5218 mL 1.0436 mL 2.6091 mL
40 mM 0.0783 mL 0.3914 mL 0.7827 mL 1.9568 mL
50 mM 0.0626 mL 0.3131 mL 0.6262 mL 1.5654 mL
60 mM 0.0522 mL 0.2609 mL 0.5218 mL 1.3045 mL
80 mM 0.0391 mL 0.1957 mL 0.3914 mL 0.9784 mL
100 mM 0.0313 mL 0.1565 mL 0.3131 mL 0.7827 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CBD3063 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBD30631281060-70-5CBD 3063CBD-3063Calcium ChannelCa2+ channelsCa channelscollapsin response mediator protein 2CRMP2Cav2.2neuropathicinflammatorypainInhibitorinhibitorinhibit

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