CBP/p300-IN-15

Cat. No.: HY-143339: FAQs
Data Sheet Handling Instructions

Molarity Calculator

CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC₅₀ values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC₅₀ values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research.

For research use only. We do not sell to patients.

CBP/p300-IN-15 Chemical Structure

CAS No. : 2379409-91-1

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Histone Acetyltransferase Isoform Specific Products:

View All Isoforms

CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

CBP

28 nM (IC₅₀)

p300

2.5 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	EC₅₀	2.71 μM Compound: 13a	Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay	[PMID: 34801827]
MV4-11	IC₅₀	64.3 nM Compound: 626; B003	Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay	[PMID: 31910017]
OVCAR-3	EC₅₀	0.865 μM Compound: 13a	Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay	[PMID: 34801827]

Molecular Weight

476.52

Formula

C₂₆H₂₈N₄O₅

CAS No.

2379409-91-1

SMILES

CNC(NC1=CC=C2C(CC[C@@]23OC(N(C3=O)CC(N4CC5=CC=CC=C5CC[C@H]4C)=O)=O)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ding H, et al. Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer. Bioorg Med Chem. 2021 Dec 15;52:116512. [Content Brief]

CBP/p300-IN-15 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBP/p300-IN-152379409-91-1Epigenetic Reader DomainHistone AcetyltransferaseHATsHATEpigeneticsHistone acetyltransferaseP300/CBPOvarian cancerH3K27OVCAR-3A2780Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks