2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. CCG-273463

CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer.

For research use only. We do not sell to patients.

CCG-273463 Chemical Structure

CCG-273463 Chemical Structure

CAS No. : 2750413-99-9

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CCG-273463 Related Antibodies

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Description

CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].

IC50 & Target

IC50: 8.6 nM (GRK5), 12 μM (GRK2)[1].
In Vitro

CCG-273463 (0.02-1 μM) potently and highly inhibits GRK5 (IC50: 8.6 nM), with inhibitory rate of 93% (GRK5) and 97% (GRK6) at 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCG-273463 Related Antibodies
Molecular Weight

521.41

Formula

C26H25BrN4O3
CAS No.
SMILES

O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(NC(CBr)=O)=C(N3)C)C)C(N[C@H](C)C4=CC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCG-273463 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCG-2734632750413-99-9CCG273463CCG 273463G Protein-coupled Receptor Kinase (GRK)Heart failurecancerhypertrophic cardiomyopathyInhibitorinhibitorinhibit

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