2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR1 antagonist 11 hydrochloride

CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases.

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CCR1 antagonist 11 hydrochloride Chemical Structure

CCR1 antagonist 11 hydrochloride Chemical Structure

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CCR1 antagonist 11 hydrochloride Related Antibodies

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Description

CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases[1].

IC50 & Target

IC50: 0.03 μM (hCCR1)，0.58 μM (mCCR1), 0.32 μM (rCCR1)[1].
In Vitro

CCR1 antagonist 11 hydrochloride(A1B1) inhibits MIP-1α-induced Ca2+ mobilization in THP-1 cells with the IC50 value of 1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCR1 antagonist 11 hydrochloride Related Antibodies
In Vivo

The pharmacokinetic parameters of CCR1 antagonist 11 hydrochloride(A1B1) in rat

Parameters PO (60 mg/kg)
t1/2 (h) 16.5
Cmax (μM/L) 0.85
AUC (h*ng/mL) 784
F (%) 95

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

466.38

Formula

C23H26Cl2FN3O2
SMILES

C[C@@H]1CN(CCN1C(/C=C/C2=C(NC(C)=O)C=C(Cl)C=C2)=O)CC3=CC=C(F)C=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCR1 antagonist 11 hydrochloride Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR1 antagonist 11CCRCC chemokine receptorCCR1hCCR1mCCR1rCCR1rheumatoid arthritisInhibitorinhibitorinhibit

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CCR1 antagonist 11 hydrochloride
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