2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR1 antagonist 12

CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC50 of 0.009 µM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model.

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CCR1 antagonist 12 Chemical Structure

CCR1 antagonist 12 Chemical Structure

CAS No. : 921208-19-7

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CCR1 antagonist 12 Related Antibodies

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Description

CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC50 of 0.009 µM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model[1].

IC50 & Target

CCR1

3 nM (IC50)

Molecular Weight

487.95

Formula

C25H27ClFN3O4
CAS No.
SMILES

CC(NC1=CC(Cl)=C(OC)C=C1/C=C/C(N2CC3COCC(N3CC4=CC=C(F)C=C4)C2)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCR1 antagonist 12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR1 antagonist 12921208-19-7CCRCC chemokine receptorEAE modelexperimental autoimmune encephalomyelitisarthritisrheumatoid arthritismultiple sclerosisTHP-1Inhibitorinhibitorinhibit

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CCR1 antagonist 12
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