CD73-IN-17

Cat. No.: HY-162918: FAQs
Data Sheet Handling Instructions

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CD73-IN-17 (compound 19) is a CD73 inhibitor with IC₅₀ of 0.1 μM for hCD73. CD73-IN-17 can be used in anti-cancer research.

For research use only. We do not sell to patients.

CD73-IN-17 Chemical Structure

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Description

CD73-IN-17 (compound 19) is a CD73 inhibitor with IC₅₀ of 0.1 μM for hCD73. CD73-IN-17 can be used in anti-cancer research^[1].

IC₅₀ & Target

CD73

0.1 ()

CD73

0.1 μM (IC₅₀)

Molecular Weight

492.87

Formula

C₂₃H₁₇ClN₆O₅

SMILES

ClC(C=N1)=CC2=C1N=NN2C3=CC=C4C(COC(C(O)=O)(C(O)=O)CC5=CC=CC=C5)=NNC4=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shi C, et al. Design, synthesis and structure-activity relationship of malonic acid non-nucleoside derivatives as potent CD73 inhibitors. Bioorg Med Chem Lett. 2024 Nov 1;112:129946. [Content Brief]

CD73-IN-17 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD73-IN-17CD73ecto-5′-nucleotidase, NT5EImmunotherapyNon-nucleoside inhibitorsInhibitorinhibitorinhibit

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