2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4/6-IN-18

CDK4/6-IN-18 (Example 2BrIC) is a selective CDK4/6 inhibitor. CDK4/6-IN-18 inhibits ionizing radiation (IR)-induced DNA damage in cells.

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CDK4/6-IN-18 Chemical Structure

CDK4/6-IN-18 Chemical Structure

CAS No. : 546102-60-7

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Based on 1 publication(s) in Google Scholar

CDK4/6-IN-18 Related Antibodies

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Description

CDK4/6-IN-18 (Example 2BrIC) is a selective CDK4/6 inhibitor. CDK4/6-IN-18 inhibits ionizing radiation (IR)-induced DNA damage in cells[1].

IC50 & Target[1]

CDK4

 

CDK6

 

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
> 20 μM
Compound: Fig 6B, R6C1
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
0.091 μM
Compound: Fig 6B, R6C1
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
0.154 μM
Compound: Fig 6B, R6C1
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
0.229 μM
Compound: Fig 6B, R6C1
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
1.5 μM
Compound: Fig 6B, R6C1
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Sf9 IC50
4 μM
Compound: Fig 6B, R6C1
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay
[PMID: 30234987]
Molecular Weight

404.22

Formula

C20H10BrN3O2
CAS No.
SMILES

O=C1NC(C2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC(Br)=C6)=O
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Storage

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Purity & Documentation
References
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CDK4/6-IN-18 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

CDK4/6-IN-18546102-60-7CDKCyclin dependent kinaseionizing radiationDNA damageInhibitorinhibitorinhibit

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