2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4/6-IN-3

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma.

For research use only. We do not sell to patients.

CDK4/6-IN-3 Chemical Structure

CDK4/6-IN-3 Chemical Structure

CAS No. : 2366237-37-6

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CDK4/6-IN-3 Related Antibodies

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Description

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1].

IC50 & Target[1]

CDK4

0.3 nM (Ki)

CDK6

2.2 nM (Ki)

CDK1

110 nM (Ki)

In Vitro

CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK4/6-IN-3 Related Antibodies
Molecular Weight

462.57

Formula

C25H31FN8
CAS No.
SMILES

FC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([C@H](C)CCCC6)N6N=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CDK4/6-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6-IN-32366237-37-6CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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