Cedazuridine hydrochloride (Synonyms: E7727 hydrochloride)

Cat. No.: HY-109081A: FAQs
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Cedazuridine (E7727) (Compound 7a) hydrochloride is an orally active cytidine deaminase (CDA) inhibitor with an IC₅₀ value of 0.4 μM. Cedazuridine hydrochloride can be used for cancer research.

For research use only. We do not sell to patients.

Cedazuridine hydrochloride Chemical Structure

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Other Forms of Cedazuridine hydrochloride:

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Purity & Documentation
References
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Description

IC₅₀ & Target

IC₅₀: 0.4 μM (CDA)^[1]

In Vitro

Cedazuridine (Compound 7a) exhibits superior acid stability^[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models^[2]
Dosage:	3 mg/kg
Administration:	Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result:	Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.

Animal Model:	NSGS male mice^[2]
Dosage:	1, 3, 10 and 30 mg/kg
Administration:	Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result:	Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.

Clinical Trial

Molecular Weight

304.68

Formula

C₉H₁₅ClF₂N₂O₅

SMILES

[H]Cl.FC1([C@H](N(CC[C@@H](O)N2)C2=O)O[C@H](CO)[C@H]1O)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ferraris D, et al. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27; 57(6):2582-8. [Content Brief]

[2]. Ramsey H E, et al. Oral azacitidine and cedazuridine approximate parenteral azacitidine efficacy in murine model. Targeted Oncology, 2020, 15(2): 231-240.

Cedazuridine hydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CedazuridineE7727E 7727E-7727Otherscytidine deaminaseCDAcancerazacitidineInhibitorinhibitorinhibit

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