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Cedazuridine  (Synonyms: E7727)

Cat. No.: HY-109081 Purity: ≥98.0%
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Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research.

For research use only. We do not sell to patients.

Cedazuridine Chemical Structure

Cedazuridine Chemical Structure

CAS No. : 1141397-80-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 192 In-stock
Solution
10 mM * 1 mL in DMSO USD 192 In-stock
Solid
1 mg USD 65 In-stock
5 mg USD 135 In-stock
10 mg USD 216 In-stock
25 mg USD 388 In-stock
50 mg USD 582 In-stock
100 mg USD 873 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cedazuridine:

Cedazuridine Related Antibodies

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Description

Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research[1].

IC50 & Target

IC50: 0.4 μM (CDA)[1]
In Vitro

Cedazuridine (Compound 7a) exhibits superior acid stability[1].
Cedazuridine (0-10 μM; 72 h) does not enhance effects of AZA (5-Azacytidine, HY-10586) in growth inhibition of AML cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cedazuridine Related Antibodies
In Vivo

Cedazuridine (3 mg/kg; p.o.; daily for 7 days) in combination with 2.5 mg/kg AZA shows tumor regression in mice MOLM-13 CDX and PDX models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSGS mice, 6–8 weeks old, human cell line-derived (CDX) and primary patient-derived xenograft (PDX) models[2]
Dosage: 3 mg/kg
Administration: Oral administration, in combination with 2.5 mg/kg AZA, daily for 7 days
Result: Led to reduction of leukemic expansion in combination with AZA in a cell line-derived xenograft transplantation, and exhibited preliminary safety and efcacy in a primary AML PDX model.
Animal Model: NSGS male mice[2]
Dosage: 1, 3, 10 and 30 mg/kg
Administration: Oral, in combination with 2.5 mg/kg AZA (Pharmacokinetic Studies)
Result: Dose-dependently increased the AUC of oral AZA and in comparison to dosing of standard i.p. AZA.
Clinical Trial
Molecular Weight

268.21

Formula

C9H14F2N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C(F)(F)[C@H](N(CC[C@@H](O)N2)C2=O)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (186.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7284 mL 18.6421 mL 37.2842 mL
5 mM 0.7457 mL 3.7284 mL 7.4568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (254 KB) HNMR (270 KB) MS (81 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7284 mL 18.6421 mL 37.2842 mL 93.2105 mL
5 mM 0.7457 mL 3.7284 mL 7.4568 mL 18.6421 mL
10 mM 0.3728 mL 1.8642 mL 3.7284 mL 9.3211 mL
15 mM 0.2486 mL 1.2428 mL 2.4856 mL 6.2140 mL
20 mM 0.1864 mL 0.9321 mL 1.8642 mL 4.6605 mL
25 mM 0.1491 mL 0.7457 mL 1.4914 mL 3.7284 mL
30 mM 0.1243 mL 0.6214 mL 1.2428 mL 3.1070 mL
40 mM 0.0932 mL 0.4661 mL 0.9321 mL 2.3303 mL
50 mM 0.0746 mL 0.3728 mL 0.7457 mL 1.8642 mL
60 mM 0.0621 mL 0.3107 mL 0.6214 mL 1.5535 mL
80 mM 0.0466 mL 0.2330 mL 0.4661 mL 1.1651 mL
100 mM 0.0373 mL 0.1864 mL 0.3728 mL 0.9321 mL
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Cedazuridine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cedazuridine1141397-80-9E7727E 7727E-7727Otherscytidine deaminaseCDAcancerazacitidineInhibitorinhibitorinhibit

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