2. Anti-infection
  3. Antibiotic Bacterial
  4. Cefotiam dihydrochloride hydrate

Cefotiam dihydrochloride hydrate  (Synonyms: SCE-963 dihydrochloride hydrate)

Cat. No.: HY-B0734B
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Cefotiam (SCE-963) dihydrochloride hydrate is a parenteral cephalosporin antibiotic. Cefotiam dihydrochloride hydrate has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

Cefotiam dihydrochloride hydrate Chemical Structure

Cefotiam dihydrochloride hydrate Chemical Structure

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Cefotiam dihydrochloride hydrate Related Antibodies

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Description

Cefotiam (SCE-963) dihydrochloride hydrate is a parenteral cephalosporin antibiotic. Cefotiam dihydrochloride hydrate has broad-spectrum activity against Gram-positive and Gram-negative bacteria[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) dihydrochloride hydrate has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1].
Cefotiam (0-6.25 μg/mL; 8 h) dihydrochloride hydrate has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefotiam dihydrochloride hydrate Related Antibodies
In Vivo

Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) dihydrochloride hydrate can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF1/b mice with P. mirabilis xenograft[1]
Dosage: 12.5, 25, 50, 100, 200, 400 and 800 mg/kg
Administration: Subcutaneous injection; twice a day, for 5 days
Result: Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.
Clinical Trial
Formula

C18H25Cl2N9O4S3.xH2O
SMILES

O=C(C(N12)=C(CSC3=NN=NN3CCN(C)C)CS[C@]2([H])[C@H](NC(CC4=CSC(N)=N4)=O)C1=O)O.[H]Cl.[H]Cl.[x].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cefotiam dihydrochloride hydrate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefotiam dihydrochlorideSCE-963 dihydrochlorideAntibioticBacterialcephalosporin antibioticgram-positive bacteriasgram-negative bacteriasantibacterial activityInhibitorinhibitorinhibit

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