Cefroxadine  (Synonyms: CGP 9000; Oraspor)

Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 10⁶ μg/mL. Cefroxadine can be used for the research of infection^[1].

Cefroxadine (10⁶-10⁸ μg/mL; overnight) shows antibacterial activities against S. aureus, E. coli, S. typhi, S. paratyphi, S. schottmuelleri, K. apneumoniae and P. mirabilis with MIC values of 1.56, 3.31, 1.56, 1.56, 1.56, 1.56 and 6.25 μg/mL respectively with a concentration of 10⁶ μg/mL^[1]. Cefroxadine (10⁴-10⁸ μg/mL; overnight) shows antibacterial activities against 100 E. coli strains with MIC₅₀ and MIC₇₅ values of 4.8-11.5 μg/mL and 6-20 μg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefroxadine (0-30 mg/kg; p.o. 0 and 3 h after infection) shows a better effect than cephalexin in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

365.40

C₁₆H₁₉N₃O₅S

51762-05-1

OC(C1=C(OC)CS[C@@]([C@@H]2NC([C@@H](C3=CCC=CC3)N)=O)([H])N1C2=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yasuda K, et al Cefroxadine (CGP-9000), an orally active cephalosporin. Antimicrob Agents Chemother. 1980 Jul;18(1):105-10.  [Content Brief]