Cemadotin hydrochloride (Synonyms: LU103793 hydrochloride)

Cat. No.: HY-13589A: FAQs
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Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer.

For research use only. We do not sell to patients.

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Cemadotin hydrochloride Chemical Structure

CAS No. : 172837-41-1

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Description	Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer^[1]^[2].
Molecular Weight	677.32
Formula	C₃₅H₅₇ClN₆O₅
CAS No.	172837-41-1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8. [Content Brief] [2]. Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):941-4. [Content Brief]

Cemadotin hydrochloride Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cemadotin172837-41-1LU103793LU 103793LU-103793Microtubule/Tubulindolastatin 15cell proliferationtumor xenograftstubulinantitumorInhibitorinhibitorinhibit

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Cemadotin hydrochloride (Synonyms: LU103793 hydrochloride)

Other Forms of Cemadotin hydrochloride:

Cemadotin hydrochloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

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