2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Cemadotin

Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer.

For research use only. We do not sell to patients.

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Cemadotin Chemical Structure

Cemadotin Chemical Structure

CAS No. : 159776-69-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Cemadotin:

Cemadotin Related Antibodies

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Description

Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1].

IC50 & Target

Ki: 1 μM (tubulin)[1]
In Vitro

Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus[1].
Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration[1].
Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency[1].
Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cemadotin Related Antibodies

Cell Proliferation Assay[2]

Cell Line: HEK 293, F9 and HL60
Concentration: 400 pM~300 nM
Incubation Time: 72 h
Result: Exhibited cytotoxicity against HEK 293, F9 and HL60 with IC50s of 0.7 nM, 14.8 nM and 0.5 nM, respectively.
Molecular Weight

640.86

Formula

C35H56N6O5
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cemadotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cemadotin159776-69-9LU103793LU 103793LU-103793Microtubule/TubulinDolastatin 15anticancerHEK 293F9HL60Inhibitorinhibitorinhibit

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