2. Anti-infection
  3. Antibiotic Bacterial
  4. Cephalochromin

Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL.

For research use only. We do not sell to patients.

Cephalochromin Chemical Structure

Cephalochromin Chemical Structure

CAS No. : 25908-26-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Cephalochromin Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
2.72 μM
Compound: Cephalochromin
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24588135]
A549 IC50
5.22 μM
Compound: Cephalochromin
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 24588135]
BHK-21 IC50
20 μM
Compound: Cephalochromin
Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
[PMID: 15387654]
Caco-2 IC50
12.4 μM
Compound: Cephalochromin
Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay
Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay
[PMID: 24588135]
Hep 3B2 IC50
14.31 μM
Compound: Cephalochromin
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
[PMID: 24588135]
HT-1080 IC50
4.98 μM
Compound: Cephalochromin
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
[PMID: 24588135]
Huh-7 IC50
4.64 μM
Compound: Cephalochromin
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay
[PMID: 24588135]
SW1353 IC50
3.54 μM
Compound: Cephalochromin
Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay
Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay
[PMID: 24588135]
Molecular Weight

518.47

Formula

C28H22O10
CAS No.
SMILES

OC(C(C(C=C1O[C@@H](C2)C)=[C@@](C(O)=C3)[C@@](C(O)=C4)=C(C=C5O[C@@H](C6)C)C(C(O)=C5C6=O)=C4O)=C3O)=C1C2=O
Structure Classification
Initial Source

Cephalosporium caerulens
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cephalochromin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cephalochromin25908-26-3AntibioticBacterialStaphylococcus aureusMRSAQRSAEscherichia coliInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Cephalochromin
Cat. No.:
HY-124199
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.