2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel Chloride Channel
  4. Cerebrocrast

Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties.

For research use only. We do not sell to patients.

Cerebrocrast Chemical Structure

Cerebrocrast Chemical Structure

CAS No. : 118790-71-9

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Cerebrocrast Related Antibodies

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Description

Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties[1][2].

In Vitro

Cerebrocrast (25 μM) inhibits the inner mitochondrial anion channel with an IC50 value of 10.5 ± 2.0 μM in rat liver mitochondria[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cerebrocrast Related Antibodies
Molecular Weight

511.56

Formula

C26H35F2NO7
CAS No.
SMILES

CCCOCCOC(C1=C(C)NC(C)=C(C(OCCOCCC)=O)C1C2=C(C=CC=C2)OC(F)F)=O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cerebrocrast Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cerebrocrast118790-71-9IOS-1.1212Calcium ChannelChloride ChannelCa2+ channelsCa channelsCl− Channels1,4-dihydropyridineblood-brain barriermitochondrianeuroprotectiveantiepilepticInhibitorinhibitorinhibit

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