Cerebrocrast (Synonyms: IOS-1.1212)

Cat. No.: HY-106808: FAQs
Data Sheet SDS COA Handling Instructions

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Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties.

For research use only. We do not sell to patients.

Cerebrocrast Chemical Structure

CAS No. : 118790-71-9

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1 mg	USD 350	Ask For Quote & Lead Time
5 mg	USD 820	Ask For Quote & Lead Time
10 mg	USD 1160	Ask For Quote & Lead Time

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

In Vitro

Cerebrocrast (25 μM) inhibits the inner mitochondrial anion channel with an IC₅₀ value of 10.5 ± 2.0 μM in rat liver mitochondria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

511.56

Formula

C₂₆H₃₅F₂NO₇

CAS No.

118790-71-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

CCCOCCOC(C1=C(C)NC(C)=C(C(OCCOCCC)=O)C1C2=C(C=CC=C2)OC(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.51%

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Data Sheet (267 KB) SDS (251 KB)

COA (249 KB) HNMR (181 KB) RP-HPLC (105 KB) LCMS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Fernandes MA, et al. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Mitochondrion. 2005 Oct;5(5):341-51. [Content Brief]

Cerebrocrast Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cerebrocrast118790-71-9IOS-1.1212Calcium ChannelChloride ChannelCa2+ channelsCa channelsCl− Channels1,4-dihydropyridineblood-brain barriermitochondrianeuroprotectiveantiepilepticInhibitorinhibitorinhibit

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