2. Others Protein Tyrosine Kinase/RTK
  3. Isotope-Labeled Compounds Anaplastic lymphoma kinase (ALK) Insulin Receptor IGF-1R
  4. Ceritinib-d7

Ceritinib-d7  (Synonyms: LDK378 d7)

Cat. No.: HY-15656S Purity: 98.00%
SDS COA Handling Instructions

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Ceritinib-d7 is a deuterium labeled Ceritinib. Ceritinib is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor[1].

For research use only. We do not sell to patients.

Ceritinib-d<sub>7</sub> Chemical Structure

Ceritinib-d7 Chemical Structure

CAS No. : 1632484-77-5

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1 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ceritinib-d7:

Ceritinib-d7 Related Antibodies

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Description

Ceritinib-d7 is a deuterium labeled Ceritinib. Ceritinib is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor[1].

Molecular Weight

565.18

Formula

C28H29D7ClN5O3S
CAS No.
Unlabeled CAS

1032900-25-6
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C2CCNCC2)C=C(OC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)=C1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 12.5 mg/mL (22.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 12.5 mg/mL (22.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7693 mL 8.8467 mL 17.6935 mL
5 mM 0.3539 mL 1.7693 mL 3.5387 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

SDS (251 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.7693 mL 8.8467 mL 17.6935 mL 44.2337 mL
5 mM 0.3539 mL 1.7693 mL 3.5387 mL 8.8467 mL
10 mM 0.1769 mL 0.8847 mL 1.7693 mL 4.4234 mL
15 mM 0.1180 mL 0.5898 mL 1.1796 mL 2.9489 mL
20 mM 0.0885 mL 0.4423 mL 0.8847 mL 2.2117 mL
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Ceritinib-d7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceritinib-d71632484-77-5LDK378 d7Isotope-Labeled CompoundsAnaplastic lymphoma kinase (ALK)Insulin ReceptorIGF-1RAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Insulin-like growth factor-1 receptorALKInsulinreceptorGF-1RSTK22DInhibitorinhibitorinhibit

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