CFL-120

Cat. No.: HY-W041315: FAQs
Data Sheet SDS COA Handling Instructions

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CFL-120 is a potent KRas^G12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer.

For research use only. We do not sell to patients.

CFL-120 Chemical Structure

CAS No. : 18711-15-4

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K-Ras H-Ras N-Ras Ras

Biological Activity
Purity & Documentation
References
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Description

CFL-120 is a potent KRas^G12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer^[1].

IC₅₀ & Target^[1]

KRAS(G12C)

In Vitro

CFL-120 (72 h) shows an antiproliferative effect with IC₅₀s of 11.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 µM for H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CFL-120 (5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments; i.p.) reduces tumor growth in subcutaneous H1792 (KRasG12C mutant) and LCLC-103H (KRasWT) human lung cancer-bearing mice^[1].
Pharmacokinetic Parameters of CFL-120 in NOD-SCID female mice^[1].

PK parameters	CFL-137
C_max (ng/mL)	337 ± 123
T_max (h)	0.25
AUC_t (ng/mL*h)	169 ± 56
t_1/2 (h)	4.4 ± 0.6
V_d (mL)	12,096 ± 4000
CL(mL/h)	1895 ± 539

NOD-SCID female mice, 15 mg/kg IP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)^[1]
Dosage:	5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments
Administration:	I.p.
Result:	Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%.

Molecular Weight

216.02

Formula

C₈H₃Cl₂NO₂

CAS No.

18711-15-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

C1=C(C=C(C2=C1NC(C2=O)=O)Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (480 KB)

COA (251 KB) HNMR (121 KB)

Handling Instructions (2659 KB)

References

[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212. [Content Brief]

CFL-120 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFL-12018711-15-4CFL120CFL 120RasH1792LCLC-103Hanticancerantiproliferativelung cancerInhibitorinhibitorinhibit

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