CFTR corrector 11

Cat. No.: HY-153133 Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CFTR corrector 11 (compound 133) is a CFTR corrector.

For research use only. We do not sell to patients.

CFTR corrector 11 Chemical Structure

CAS No. : 688050-45-5

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

CFTR corrector 11 (compound 133) is a CFTR corrector^[1].

Molecular Weight

345.39

Formula

C₁₈H₂₃N₃O₄

CAS No.

688050-45-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NOC(C2=CC=C(OC)C=C2)=C1)NCCCN3CCOCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (180.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8953 mL	14.4764 mL	28.9528 mL
5 mM	0.5791 mL	2.8953 mL	5.7906 mL
10 mM	0.2895 mL	1.4476 mL	2.8953 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (245 KB) HNMR (243 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Bradley Tait, et al. Methods of modulating cftr activity. WO2014210159A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8953 mL	14.4764 mL	28.9528 mL	72.3819 mL
	5 mM	0.5791 mL	2.8953 mL	5.7906 mL	14.4764 mL
	10 mM	0.2895 mL	1.4476 mL	2.8953 mL	7.2382 mL
	15 mM	0.1930 mL	0.9651 mL	1.9302 mL	4.8255 mL
	20 mM	0.1448 mL	0.7238 mL	1.4476 mL	3.6191 mL
	25 mM	0.1158 mL	0.5791 mL	1.1581 mL	2.8953 mL
	30 mM	0.0965 mL	0.4825 mL	0.9651 mL	2.4127 mL
	40 mM	0.0724 mL	0.3619 mL	0.7238 mL	1.8095 mL
	50 mM	0.0579 mL	0.2895 mL	0.5791 mL	1.4476 mL
	60 mM	0.0483 mL	0.2413 mL	0.4825 mL	1.2064 mL
	80 mM	0.0362 mL	0.1810 mL	0.3619 mL	0.9048 mL
	100 mM	0.0290 mL	0.1448 mL	0.2895 mL	0.7238 mL