2. Membrane Transporter/Ion Channel
  3. CFTR
  4. CFTR corrector 8

CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis.

For research use only. We do not sell to patients.

CFTR corrector 8 Chemical Structure

CFTR corrector 8 Chemical Structure

CAS No. : 1918142-35-4

Size Price Stock Quantity
5 mg USD 220 In-stock
10 mg USD 340 In-stock
25 mg USD 680 In-stock
50 mg USD 1090 In-stock
100 mg USD 1750 In-stock
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Based on 1 publication(s) in Google Scholar

CFTR corrector 8 Related Antibodies

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  • Purity & Documentation

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Description

CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1].

In Vitro

CFTR corrector 8 (compound 12) shows EC50s of 1 μM (CSE-HRP assay) and 3 μM (HBE-TECC assay) [1].
CFTR corrector 8 exhibits hepatocyte clearance rate of 1250/775 L/hr/kg (human/rat)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CFTR corrector 8 Related Antibodies
Molecular Weight

539.52

Formula

C29H27F2NO7
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (203.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8535 mL 9.2675 mL 18.5350 mL
5 mM 0.3707 mL 1.8535 mL 3.7070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8535 mL 9.2675 mL 18.5350 mL 46.3375 mL
5 mM 0.3707 mL 1.8535 mL 3.7070 mL 9.2675 mL
10 mM 0.1853 mL 0.9267 mL 1.8535 mL 4.6337 mL
15 mM 0.1236 mL 0.6178 mL 1.2357 mL 3.0892 mL
20 mM 0.0927 mL 0.4634 mL 0.9267 mL 2.3169 mL
25 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8535 mL
30 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5446 mL
40 mM 0.0463 mL 0.2317 mL 0.4634 mL 1.1584 mL
50 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
60 mM 0.0309 mL 0.1545 mL 0.3089 mL 0.7723 mL
80 mM 0.0232 mL 0.1158 mL 0.2317 mL 0.5792 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.4634 mL
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CFTR corrector 8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFTR corrector 81918142-35-4CFTR corrector8CFTR corrector-8CFTRCystic fibrosis transmembrane conductance regulatorCystic fibrosisCSE-HRP assayHBE-TECC assayInhibitorinhibitorinhibit

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