2. GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Adenosine Receptor p38 MAPK Phosphodiesterase (PDE)
  4. CGH2466 dihydrochloride

CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC50 values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC50 = 187~ 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

CGH2466 dihydrochloride Chemical Structure

CGH2466 dihydrochloride Chemical Structure

CAS No. : 1177618-54-0

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CGH2466 dihydrochloride Related Antibodies

Top Publications Citing Use of Products

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC50 values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC50 = 187~ 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD)[1].

IC50 & Target

A1

19 nM (IC50)

A2B

21 nM (IC50)

A3

80 nM (IC50)

Molecular Weight

395.13

Formula

C14H11Cl4N3S
CAS No.
SMILES

NC1=NC(C2=CC=C(Cl)C(Cl)=C2)=C(C3=CC=NC=C3)S1.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CGH2466 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGH24661177618-54-0CGH 2466CGH-2466Adenosine Receptorp38 MAPKPhosphodiesterase (PDE)P1 receptorasthmachronic obstructive pulmonary disease (COPD)Inhibitorinhibitorinhibit

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