2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. CHDI-00484077

CHDI-00484077 (Compound 12) is a CNS-penetrant class IIa HDAC inhibitor, with IC50s of 0.01 μM (HDAC4), 0.02 μM(HDAC5), 0.02 μM (HDAC7), 0.03 μM (HDAC9) respectively. CHDI-00484077 can be used for research of huntington’s disease.

For research use only. We do not sell to patients.

CHDI-00484077 Chemical Structure

CHDI-00484077 Chemical Structure

CAS No. : 3025894-92-9

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CHDI-00484077 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

CHDI-00484077 (Compound 12) is a CNS-penetrant class IIa HDAC inhibitor, with IC50s of 0.01 μM (HDAC4), 0.02 μM(HDAC5), 0.02 μM (HDAC7), 0.03 μM (HDAC9) respectively. CHDI-00484077 can be used for research of huntington’s disease[1].

IC50 & Target[1]

HDAC4

0.01 μM (IC50)

HDAC5

0.02 μM (IC50)

HDAC7

0.02 μM (IC50)

HDAC9

0.03 μM (IC50)

HDAC1

17 μM (IC50)

HDAC2

27 μM (IC50)

HDAC3

10 μM (IC50)

HDAC8

2.0 μM (IC50)

HDAC6

22 μM (IC50)

Molecular Weight

382.38

Formula

C18H21F3N4O2
CAS No.
SMILES

FC(F)(C1=NC(C2=CC=C(C=C2)C(N[C@H](C)CN3[C@H](CCC3)C)=O)=NO1)F
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHDI-00484077 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHDI-004840773025894-92-9CHDI00484077CHDI 00484077HDACHistone deacetylaseshuntington’sInhibitorinhibitorinhibit

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