2. Anti-infection
  3. Flavivirus
  4. CHIKV-IN-5

CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV.

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CHIKV-IN-5 Chemical Structure

CHIKV-IN-5 Chemical Structure

CAS No. : 2568903-91-1

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CHIKV-IN-5 Related Antibodies

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Description

CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV[1].

In Vitro

CHIKV-IN-5 shows good virus titer reduction (VTR = 8.7 log at 10 μM concentration) in normal human dermal fibroblast cells and in vitro mouse microsomal stability (MLMt1/2=74 min)[1].
CHIKV-IN-5 (10 μM, 2 h) blocks CHIKV replication post-entry on NHDF cells[1].
CHIKV-IN-5 (10 μM, pretreats for 1 h) inhibits CHIKV structural protein synthesis but not viral transcription in CHIKV infected NHDF cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHIKV-IN-5 Related Antibodies
In Vivo

CHIKV-IN-5 (80 mg/kg, i.p., twice a day, 3 days) reduces footpad swelling and significantly decrease virus dissemination to other tissues in CHIKV-infected mice [1].
CHIKV-IN-5 (0.5-20 mg/kg, i.p., i.v., p.o., s.c.) shows favorable metabolic stability in male C57BL/6 mice [1].
Pharmacokinetic (PK) analysis in mice (CHIKV-IN-5)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

parameters i.v. i.p. p.o. s.c.
t1/2 (h) 1.78 3.52 2.38 5.70
AUC (h × ng/mL) 821 30648 15292 1524
Cmax (ng/mL) - 2460 2100 142
%F - 91 45 5
Animal Model: CHIKV-infected male C57BL/6 mice (1000 PFU CHIKV181/25 in a 20 μL volume)[1]
Dosage: 80 mg/kg
Administration: Intraperitoneal injection (i.p.), twice a day, 3 days
Result: Reduced footpad swelling as a result of infection.
Significant reduction in secondary tissue spread to the spleen and right quadriceps tissues was detected.
Animal Model: Male C57BL/6 mice[1]
Dosage: i.v.:0.5 mg/mL, p.o., s.c., i.p.: 20 mg/mL
Administration: Intravenous (i.v.), Intraperitoneal (i.p.), Oral (p.o.), Subcutaneous (s.c.)
Result: Displayed good parameters by the i.p. route with the longest t1/2 time (3.52 h), highest concentration (2460 ng/mL) and greatest bioavailability (91%).
Molecular Weight

443.54

Formula

C23H17N5OS2
CAS No.
SMILES

O=C(NC1=NC(C2=CC(NC3=CC=C(C=C3)C#N)=CC=C2)=CS1)C4=C(N=CC=C4)SC
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHIKV-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHIKV-IN-52568903-91-1FlavivirusVirusInfectionNHDF cellsMicrosomalAntiviral activityReplicationInhibitorinhibitorinhibit

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