Chisocheton compound F

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Chisocheton compound F is a nature product that could be isolated from the stem bark of Melia toosendan.

For research use only. We do not sell to patients.

Chisocheton compound F Chemical Structure

CAS No. : 157376-71-1

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Biological Activity
Purity & Documentation
References
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Description

Chisocheton compound F is a nature product that could be isolated from the stem bark of Melia toosendan^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 20 μM Compound: 12	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
AZ-521 cell line	IC₅₀	> 20 μM Compound: 12	Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
DLD-1	IC₅₀	31.7 μM Compound: 2	Cytotoxicity against Wnt-dependent human DLD1 cells assessed as cell viability after 24 hrs by fluorescence assay Cytotoxicity against Wnt-dependent human DLD1 cells assessed as cell viability after 24 hrs by fluorescence assay	[PMID: 25905468]
HCT-116	IC₅₀	24.4 μM Compound: 2	Cytotoxicity against Wnt-dependent human HCT116 cells assessed as cell viability after 24 hrs by fluorescence assay Cytotoxicity against Wnt-dependent human HCT116 cells assessed as cell viability after 24 hrs by fluorescence assay	[PMID: 25905468]
HEK293	IC₅₀	3 μM Compound: 2	Activation of GSK-3beta in HEK293 cells assessed as suppression of TCF/beta-catenin transcriptional activity after 24 hrs by SuperTOPFlash reporter gene assay Activation of GSK-3beta in HEK293 cells assessed as suppression of TCF/beta-catenin transcriptional activity after 24 hrs by SuperTOPFlash reporter gene assay	[PMID: 25905468]
HEK293	IC₅₀	31.2 μM Compound: 2	Cytotoxicity against HEK293 cells assessed as cell viability after 24 hrs by fluorescence assay Cytotoxicity against HEK293 cells assessed as cell viability after 24 hrs by fluorescence assay	[PMID: 25905468]
HEK-293T	IC₅₀	> 40 μM Compound: 2	Cytotoxicity against HEK293T cells assessed as cell viability after 24 hrs by fluorescence assay Cytotoxicity against HEK293T cells assessed as cell viability after 24 hrs by fluorescence assay	[PMID: 25905468]
HL-60	IC₅₀	> 20 μM Compound: 12	Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
RKO	IC₅₀	26.4 μM Compound: 2	Cytotoxicity against Wnt-independent human RKO cells assessed as cell viability after 24 hrs by fluorescence assay Cytotoxicity against Wnt-independent human RKO cells assessed as cell viability after 24 hrs by fluorescence assay	[PMID: 25905468]
SK-BR-3	IC₅₀	> 20 μM Compound: 12	Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
SW480	IC₅₀	11.2 μM Compound: 2	Cytotoxicity against Wnt-independent human SW480 cells assessed as cell viability after 24 hrs by fluorescence assay Cytotoxicity against Wnt-independent human SW480 cells assessed as cell viability after 24 hrs by fluorescence assay	[PMID: 25905468]

Molecular Weight

454.60

Formula

C₂₈H₃₈O₅

CAS No.

157376-71-1

SMILES

CC(O[C@@H]1C[C@H]2C(C)(C(C=C[C@@]2([C@H]3CC[C@@]4(C([C@]13C)=CC[C@H]4[C@@H]5CC(OC5)=O)C)C)=O)C)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et, al. Limonoids and triterpenoids from the stem bark of Melia toosendan. J Nat Prod. 2010 Apr 23;73(4):664-8. [Content Brief]