Chloranthalactone B 

Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways^[1].

Chloranthalactone B (6.25-50 µM; 30 min) has anti-inflammatory effects in LPS-stimulated RAW264.7 cells and inhibits NO production^[1].
Chloranthalactone B (25 and 50 µM; 30 min) inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) expression in LPS-treated RAW264.7 cells^[1].
Chloranthalactone B (25 and 50 µM; RAW264.7 cells) inhibits LPS-induced AP-1 activation in a concentration-dependent manner^[1].
Chloranthalactone B (25 and 50 µM; 30 min; RAW264.7 cells) inhibits the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

244.29

C₁₅H₁₆O₃

66395-03-7

C[C@@]12[C@@]3([H])[C@]4(O3)C(C[C@@]1([H])C([C@]5([H])[C@@]2([H])C5)=C)=C(C(O4)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li X, et, al. Anti-Inflammatory Effects of Chloranthalactone B in LPS-Stimulated RAW264.7 Cells. Int J Mol Sci. 2016 Nov 22;17(11):1938.  [Content Brief]