Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) generates lipid-based ROS and induce ferroptosis

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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Chemical Structure

CAS No. : 39916-28-4

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Description	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) generates lipid-based ROS and induce ferroptosis
In Vitro	Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) exhibits anti-cancer activity in BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC₅₀s = 0.07, 2.5, 1.5, 3, and 5 µM, respectively)^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Related Antibodies
Molecular Weight	405.64
Formula	C₂₀H₁₄ClFeN₂O₂
CAS No.	39916-28-4
SMILES	[Cl-][Fe+3]123[O-]C4=C(C=[N]1C5=C([N]2=CC6=C([O-]3)C=CC=C6)C=CC=C5)C=CC=C4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (280 KB) Handling Instructions (2659 KB)
References	[1]. Jessica Sagasser, et al. A New Approach in Cancer Treatment: Discovery of Chlorido[ N, N'-disalicylidene-1,2-phenylenediamine]iron(III) Complexes as Ferroptosis Inducers. J Med Chem. 2019 Sep 12;62(17):8053-8061. [Content Brief] [2]. Soo-Young Lee, et al. [FeIII (salophene) Cl], a potent iron salophene complex overcomes multiple drug resistance in lymphoma and leukemia cells. Leukemia Research 35 (2011) 387-393.

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)39916-28-4Reactive Oxygen SpeciesFerroptosisInhibitorinhibitorinhibit

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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)

Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) Related Antibodies

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